Biomedical Sensors and Subsystems

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Braille-Driven Aqueous Two-Phase System Droplet Microfluidic System
David Lai, John P. Frampton, Hari Sriram, and Shuichi Takayama
Aqueous Two Phase System monodisperse droplets of dextran-heavy phase in PEG-heavy phase with very low interfacial tension. Droplets in motion assume a teardrop shape due to high capillary number but conform to a spherical shape when flow is terminated.
Aqueous Two Phase System monodisperse droplets of dextran-heavy phase in PEG-heavy phase with very low interfacial tension. Droplets in motion assume a teardrop shape due to high capillary number but conform to a spherical shape when flow is terminated.

A microfluidic system capable of creating aqueous two-phase system (ATPS) droplets where one aqueous phase forms droplets and the other aqueous phase forms the surrounding matrix. Unlike water-in-oil droplet systems, ATPS can have very low interfacial tensions that prevent spontaneous droplet formation through instabilities. We demonstrate the formation of ATPS droplet formation with the lowest interfacial tension to date and applied them to patterning alternating islands of two different cell types within a single microfluidic channel.

Updated 05/02/2012