Biomedical Sensors and Subsystems

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Micro- & Nanofluidics and Cellular Environomics
Toshiki Mastuoka, Byoung Choul Kim, and Shuichi Takayama
Figure. Size-adjustable elastomeric nanochannels. a, The system has an array of nanochannels spanning microscale inlet and outlet compartments separated by 500 μm. Fluorescein molecules introduced into the inlet are transported through the nanochannels by electrokinetic flows . b, Channel deformation at certain pressure resulted in stretching of single DNA
Figure. Size-adjustable elastomeric nanochannels. a, The system has an array of nanochannels spanning microscale inlet and outlet compartments separated by 500 μm. Fluorescein molecules introduced into the inlet are transported through the nanochannels by electrokinetic flows . b, Channel deformation at certain pressure resulted in stretching of single DNA

Fluidic transport through nanochannels offers new opportunities to probe fundamental nanoscale transport phenomena and to develop tools for manipulating DNA, proteins, small molecules and nanoparticles. We use nanoscale fracturing of oxidized poly(dimethylsiloxane) to conveniently fabricate nanofluidic systems with arrays of nanochannels to actively manipulate nanofluidic transport through dynamic modulation of the channel cross-section. The process is designed to achieve reversible nanochannel deformation using remarkably small forces. We demonstrate the versatility of the elastomeric nanochannels through tuneable sieving; trapping of nanoparticles and dynamic manipulation of the conformation of single DNA molecules.

Updated 03/30/2012