Biomedical Sensors and Subsystems

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Microdroplet Enabled Parallel Co-Cultivation of Symbiotic Microbial Communities
Jihyang Park and Mark A. Burns
(left) Schematic of the interdependency between symbiotic microbes; (right) Three steps for analysis of symbiotic microbes
(left) Schematic of the interdependency between symbiotic microbes; (right) Three steps for analysis of symbiotic microbes

A microfluidic device for:

1. Encapsulation of subsets of microbiota - Multiple droplet generation by slanted T-junction geometry
2. Cultivation of microbial subsets - Monitoring of cell growth by microscopy
3. Analysis of cultivated communities

using monodispersed droplets in oil phase. The technology is being applied to cultivation of tunicate microbiota to isolate E.frumentensis, an anti-cancer drug producing bacterium.

Updated 06/13/2011